Guanidine Hydrochloride → 2-Amino-7-phenyl-7,8-dihydro-6H-quinazolin-5-one

HRID 2046453ノート

反応式

HRID 2046453 の反応式
CN(C=C1C(=O)CC(C2C=CC=CC=2)CC1=O)C.Cl.NC(N)=N.C(=O)([O-])[O-].[Na+].[Na+].[NH2:30][C:31]1[N:40]=[CH:39][C:38]2[C:37](=[O:41])[CH2:36][CH:35]([C:42]3[CH:47]=[CH:46][C:45](Cl)=[CH:44][CH:43]=3)[CH2:34][C:33]=2[N:32]=1>>[NH2:30][C:31]1[N:40]=[CH:39][C:38]2[C:37](=[O:41])[CH2:36][CH:35]([C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=3)[CH2:34][C:33]=2[N:32]=1

参加物

5

反応物 4

HCID 5742Guanidine HydrochlorideHCID 10340Sodium CarbonateHCID 27723712-amino-7-(4-chlorophenyl)-7,8-dihydroquinazolin-5(6H)-oneHCID 108901102-Dimethylaminomethylene-5-phenyl-cyclohexane-1,3-dione

生成物 1

HCID 27723882-Amino-7-phenyl-7,8-dihydro-6H-quinazolin-5-one

実験手順

The title compound was prepared from 2-dimethylaminomethylene-5-phenyl-cyclohexane-1,3-dione (600 mg, 2.46 mmol) from stage 1, guanidine hydrochloride (473 mg, 4.94 mmol) and sodium carbonate (783 mg, 7.38 mmol), following the procedure described for the synthesis of 2-amino-7-(4-chloro-phenyl)-7,8-dihydro-6H-quinazolin-5-one (example 2/a stage 2) except that the mixture was heated to reflux for 16 h.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 16 h.

出典と根拠

ORDレコード
ord-00e901b3457a40659bad10fc09e11b0b
出典データセット
uspto-grants-2013_11
特許番号
US08592430B2

反応ノート

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