Water → 5-Fluoro-6-(2,3,5-trifluorophenyl)picolinic acid

HRID 2046873ノート

反応式

HRID 2046873 の反応式
[F:1][C:2]1[C:3]([C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[C:11]([F:16])[C:10]=2[F:17])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[Mn]([O-])(=O)(=O)=[O:19].[K+].[OH2:24]>CC(O)(C)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:19])=[O:24])=[N:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[C:11]([F:16])[C:10]=1[F:17]

参加物

5

反応物 3

HCID 962WaterHCID 516875Potassium PermanganateHCID 592265243-Fluoro-6-methyl-2-(2,3,5-trifluorophenyl)pyridine

生成物 1

HCID 592264915-Fluoro-6-(2,3,5-trifluorophenyl)picolinic acid収率 89%

試薬・触媒・溶媒 1

HCID 6386tert-Butanol溶媒

反応条件

温度
90 °C

実験手順

To a solution of 3-fluoro-6-methyl-2-(2,3,5-trifluorophenyl)pyridine (1.0 equiv.) in water and t-BuOH (2:1, 0.06 M) was added potassium permanganate (10 equiv.) and the solution was heated at 90° C. for 5 hours. Upon cooling to room temperature, the solution was filtered, and the filtrate was concentrated under reduced pressure to yield 5-fluoro-6-(2,3,5-trifluorophenyl)picolinic acid in 89% yield. LC/MS=272.0 (M+H), Rt=0.80 min.

後処理

  1. temperatureUpon cooling to room temperature
  2. filtrationthe solution was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-563ad27c1a1f468aa4fc66f317dec206
出典データセット
uspto-grants-2013_11
特許番号
US08592455B2

反応ノート

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