Methyl iodide → HCID 178503522、化合物
反応式
[OH:1][C:2]1[N:7]=[C:6]([SH:8])[N:5]=[C:4]2[NH:9][N:10]=[CH:11][C:3]=12.[CH3:12]I>[OH-].[Na+].O>[OH:1][C:2]1[N:7]=[C:6]([S:8][CH3:12])[N:5]=[C:4]2[NH:9][N:10]=[CH:11][C:3]=12参加物
5
反応条件
- 温度
- 5 °C
実験手順
4-hydroxy-6-mercapto-pyrazolo[3,4-d]pyrimidine (14 g) was dissolved in a solution of sodium hydroxide (10 g) in water (300 mL). The solution was cooled to 5° C. and shaken with of methyl iodide (12 g). After 15-20 minutes the solution was charcoaled, filtered and acidified with acetic acid to yield crude product. Re-crystallization in acid gave the desired product MS (ES+): 183.0 (M+1)+.
後処理
- filtrationfiltered
- customto yield crude product
出典と根拠
- ORDレコード
- ord-9fa22ab145f44a6e8e4789609f61c6eb
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08592432B2
反応ノート
読み込み中…