Sodium borohydride → 1-[3-(1H-Benzoimidazol-2-yl)-4-chloro-phenyl]-piperidin-4-ol

HRID 2047381

反応式

HRID 2047381 の反応式
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[CH:11]=[C:12]([N:17]2[CH2:22][CH2:21][C:20](=[O:23])[CH2:19][CH2:18]2)[CH:13]=[CH:14][C:15]=1[Cl:16].[BH4-].[Na+]>CO>[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[CH:11]=[C:12]([N:17]2[CH2:22][CH2:21][CH:20]([OH:23])[CH2:19][CH2:18]2)[CH:13]=[CH:14][C:15]=1[Cl:16]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 595682431-[3-(1H-benzo[d]imidazol-2-yl)-4-chlorophenyl]piperidin-4-one

生成物 1

HCID 595683691-[3-(1H-Benzoimidazol-2-yl)-4-chloro-phenyl]-piperidin-4-ol収率 36%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a suspension of 1-[3-(1H-benzoimidazol-2-yl)-4-chloro-phenyl]-piperidin-4-one (0.05 g, 0.17 mmol) in methanol (50 mL) was added sodium borohydride (NaBH4) (0.01 g, 0.17 mmol) and the resulting mixture was stirred for 1 h at room temperature and then quenched with few drops of water. The solvent was removed under reduced pressure, the crude dissolved in EtOAc (5 mL) and filtered, then the organic phase was evaporated under reduced pressure to afford 0.02 g (36%) of the title compound.

後処理

  1. customquenched with few drops of water
  2. customThe solvent was removed under reduced pressure
  3. dissolutionthe crude dissolved in EtOAc (5 mL)
  4. filtrationfiltered
  5. customthe organic phase was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-b68508f9a2104c64b457a0df3cd08835
出典データセット
uspto-grants-2013_11
特許番号
US08592463B2

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