Hydrogen Bromide → 1-(3-Hydroxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone

HRID 2049656

反応式

HRID 2049656 の反応式
C[O:2][C:3]1[CH:4]=[C:5]([C:9](=[O:17])[CH2:10][CH:11]2[CH2:15][CH2:14][CH2:13][N:12]2[CH3:16])[CH:6]=[CH:7][CH:8]=1.Br>C(O)(=O)C>[OH:2][C:3]1[CH:4]=[C:5]([C:9](=[O:17])[CH2:10][CH:11]2[CH2:15][CH2:14][CH2:13][N:12]2[CH3:16])[CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 203441421-(3-Methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone

生成物 1

HCID 203441401-(3-Hydroxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

40.5 of 1-(3-methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone are boiled under reflux for 6 hours with 180 ml of acetic acid and 180 ml of 47% hydrobromic acid. After concentration of the solution, the oily residue is brought to crystallization through treatment with 150 ml of hot ethanol. Cooling is allowed to take place, and 39.8 g (76% of theory) of the hydrobromide of the title compound is filtered off as greenish crystals: m.p. 165° to 168°.

後処理

  1. customAfter concentration of the solution, the oily residue is brought to crystallization through treatment with 150 ml of hot ethanol
  2. temperatureCooling
  3. filtrationis filtered off as greenish crystals

出典と根拠

ORDレコード
ord-de4b1731d35c4d0a8b1e8f23c53058e2
出典データセット
uspto-grants-1980_04
特許番号
US04198424

関連ノート

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