Acetophenone → 1-(4-Methylphenyl)-3-phenylpropane-1,3-dione

HRID 2051052

反応式

HRID 2051052 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].C[C:11]1[CH:12]=[C:13]([C:18]([O:20]C)=O)[C:14](C)=[CH:15][CH:16]=1.[CH3:22][O-].[Na+]>C1(C)C(C)=CC=CC=1>[C:1]([CH2:2][C:18](=[O:20])[C:13]1[CH:12]=[CH:11][C:16]([CH3:22])=[CH:15][CH:14]=1)(=[O:3])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 7410AcetophenoneHCID 273300Methyl 2,5-dimethylbenzoateHCID 10942334Sodium Methoxide

生成物 1

HCID 7811081-(4-Methylphenyl)-3-phenylpropane-1,3-dione

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

Acetophenone (30 grams; 0,25 mol), methyl p-methyltoluate (136 grams; 1.0 mol), xylene (300 ml) and sodium methoxide (17.3 grams; 0.3 mol) were placed into a four-necked round bottom one liter flask equipped as in Example 1. The mixture was heated with stirring to 135°-140° C. and maintained there for 6 hours under a blanket of nitrogen. The procedure set forth in Example 1 was used to recover the desired product, benzoyl p-methylbenzoylmethane (40 grams; 67 weight percent yield) having a purity of 66%.

後処理

  1. customequipped as in Example 1
  2. temperatureThe mixture was heated
  3. temperaturemaintained there for 6 hours under a blanket of nitrogen
  4. customto recover the desired product, benzoyl p-methylbenzoylmethane (40 grams; 67 weight percent yield)

出典と根拠

ORDレコード
ord-7643653de6e9428088e520bee637b9e5
出典データセット
uspto-grants-1991_05
特許番号
US05015777

関連ノート

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