O-Phenylenediamine → methyl 2-(3-oxo-4H-quinoxalin-2-yl)acetate

HRID 2051651ノート

反応式

HRID 2051651 の反応式
[C:1]([C:7]([O:9][CH3:10])=[O:8])#[C:2][C:3](OC)=[O:4].[C:11]1([NH2:18])[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[NH2:17]>CO>[O:4]=[C:3]1[NH:18][C:11]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:17]=[C:2]1[CH2:1][C:7]([O:9][CH3:10])=[O:8]

参加物

4

反応物 2

HCID 7243O-PhenylenediamineHCID 12980Dimethyl acetylenedicarboxylate

生成物 1

HCID 310826methyl 2-(3-oxo-4H-quinoxalin-2-yl)acetate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Dimethyl acetylenedicarboxylate (31.2 g., 0.22 mol.) was added slowly to a solution of o-phenylenediamine (21.6 g., 0.2 mol.) in methanol (400 ml.). The reaction mixture was stirred at room temperature for three hours and then cooled in an ice bath. The yellow solid was collected and washed with cold methanol. The solid was recrystallized from tetrahydrofuran (27.7 g., m.p. 230-232° dec.).

後処理

  1. temperaturecooled in an ice bath
  2. customThe yellow solid was collected
  3. washwashed with cold methanol
  4. customThe solid was recrystallized from tetrahydrofuran (27.7 g., m.p. 230-232° dec.)

出典と根拠

ORDレコード
ord-3ae0d82566484b629e6bfd15a5fd844d
出典データセット
uspto-grants-1980_01
特許番号
US04181724

反応ノート

読み込み中…