3-(4-Fluorophenoxy)propionic acid → 1-Propanol, 2-(4-fluorophenoxy)-

HRID 2051928ノート

反応式

HRID 2051928 の反応式
B#B.[F:3][C:4]1[CH:15]=[CH:14][C:7]([O:8][CH:9]([CH3:13])[C:10](O)=[O:11])=[CH:6][CH:5]=1>O1CCCC1>[F:3][C:4]1[CH:15]=[CH:14][C:7]([O:8][CH:9]([CH3:13])[CH2:10][OH:11])=[CH:6][CH:5]=1

参加物

4

反応物 2

HCID 38721403-(4-Fluorophenoxy)propionic acidHCID 6328200Diboron

生成物 1

HCID 104647301-Propanol, 2-(4-fluorophenoxy)-

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To 95 ml. of diborane in 95 ml. of tetrahydrofuran was added 10.2 g. of 2-(4-fluorophenoxy)propionic acid in 100 ml. of tetrahydrofuran. The reaction mixture was stirred at room temperature for 20 hours. The solution was gradually poured onto 600 g. of ice and extracted (3×-250 ml each) with chloroform. The combined organic layer was extracted with water (3×-50 ml each) and dried. The solvent was removed under vacuum giving a clear liquid.

後処理

  1. additionThe solution was gradually poured onto 600 g
  2. extractionof ice and extracted (3×-250 ml each) with chloroform
  3. extractionThe combined organic layer was extracted with water (3×-50 ml each)
  4. customdried
  5. customThe solvent was removed under vacuum
  6. customgiving a clear liquid

出典と根拠

ORDレコード
ord-2b65110274a9450c852a727ab72536fe
出典データセット
uspto-grants-1980_01
特許番号
US04182776

反応ノート

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