HCID 11528683、化合物 → (6S)-6-Methyl-7-(tetrahydro-2H-pyran-2-yloxy)heptan-2-one
反応式
[CH3:1][C@H:2]([CH2:9][O:10][CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][O:12]1)[CH2:3][C:4]#[C:5][C:6](=[O:8])[CH3:7].[H][H]>[Pd].C1COCC1>[CH3:1][C@H:2]([CH2:9][O:10][CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][O:12]1)[CH2:3][CH2:4][CH2:5][C:6](=[O:8])[CH3:7]参加物
5
実験手順
A 50 g solution (222.9 mmol) of (S)-6-methyl-7-[(RS)-(3,4,5,6-tetrahydro-2H-pyran-2-yl)oxy]hept-3-in-2-one and 5 g palladium on carbon (10% Pd/C) in 400 ml of THF is hydrogenated for one hour at 8 bar hydrogen at room temperature. The catalyst is then filtered off, rewashed with little solvent and the solvent is removed in vacuo. 50.9 g of product is obtained.
後処理
- filtrationThe catalyst is then filtered off
- customthe solvent is removed in vacuo
出典と根拠
- ORDレコード
- ord-f341d14b8c8540eabe506c23d45a5a08
- 出典データセット
- uspto-grants-2008_02
- 特許番号
- US07326798B2
反応ノート
読み込み中…