Chlorine → HCID 178474789、化合物

HRID 2054047ノート

反応式

HRID 2054047 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]([C:11]([NH:13][C@H:14]([C:16]2[NH:20][C:19]3[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:18]=3[N:17]=2)[CH3:15])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N(C(C)C)CC)(C)C.[C:57]([N:60]([CH2:62][C@H:63]1[CH2:67][CH2:66][CH2:65][NH:64]1)[CH3:61])(=[O:59])[CH3:58].ClCl>O1CCCC1.ClCCl.C(O)C>[C:57]([N:60]([CH2:62][C@H:63]1[CH2:67][CH2:66][CH2:65][N:64]1[C:4]([C:3]1[CH:7]=[CH:8][C:9]([C:11]([NH:13][C@H:14]([C:16]2[NH:20][C:19]3[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:18]=3[N:17]=2)[CH3:15])=[O:12])=[CH:10][C:2]=1[Cl:1])=[O:5])[CH3:61])(=[O:59])[CH3:58]

参加物

8

反応物 5

HCID 24526ChlorineHCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 45088475(R)-N-Methyl-N-(pyrrolidin-2-ylmethyl)acetamideHCID 178462084(1S)-2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid

生成物 1

HCID 178474789HCID 178474789、化合物収率 17%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 21584144Dichloromethane ethanol溶媒

実験手順

Prepared analogously to Example 1g from (1S)-2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, TBTU, diisopropylethylamine, and (R)-2-[(N-acetyl-N-methylamino)methyl]pyrrolidine in tetrahydrofuran. Yield: 17%; Rf value: 0.40 (silica gel: dichloromethane/ethanol=9:1); C25H27Cl2N5O3 (516.426); mass spectrum: (M+H)+=516/518/520 (chlorine isotope).

出典と根拠

ORDレコード
ord-8f96926145aa48ac9aa909ead9636420
出典データセット
uspto-grants-2008_02
特許番号
US07326791B2

反応ノート

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