Triethylamine → {4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone

HRID 2054692

反応式

HRID 2054692 の反応式
C(N1C=CN=C1)(N1C=CN=C1)=O.[C:13]1([C:23]([OH:25])=O)[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][N:14]=1.[F:26][C:27]1[CH:32]=[CH:31][C:30]([CH2:33][CH2:34][N:35]2[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]2)=[CH:29][CH:28]=1.C(N(CC)CC)C>O1CCCC1>[F:26][C:27]1[CH:32]=[CH:31][C:30]([CH2:33][CH2:34][N:35]2[CH2:36][CH2:37][N:38]([C:23]([C:13]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[CH:16]=[CH:15][N:14]=3)=[O:25])[CH2:39][CH2:40]2)=[CH:29][CH:28]=1

参加物

6

反応物 4

HCID 8471TriethylamineHCID 68092Isoquinoline-1-carboxylic acidHCID 682631,1'-CarbonyldiimidazoleHCID 112545221-(2-(4-Fluorophenyl)ethyl)piperazine

生成物 1

HCID 9885359{4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

0.9 g of 1,1′-carbonyldiimidazole is added to a solution of 1 g of isoquinoline-1-carboxylic acid in 100 ml of tetrahydrofuran (THF), and the mixture is stirred at room temperature for 2 hours. 1.6 g of 1-[2-(4-fluorophenyl)ethyl]piperazine and 2.4 ml of triethylamine are added to this mixture, which is stirred for a further 80 hours. ConventionaL work-up gives {4-[2-(4-fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone.

後処理

  1. stirringis stirred for a further 80 hours

出典と根拠

ORDレコード
ord-0e1702a7d52d463ea9f47c16268678c6
出典データセット
uspto-grants-2008_02
特許番号
US07329749B2

関連ノート

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