Sodium Hydroxide → HCID 178461815、化合物

HRID 20547

反応式

HRID 20547 の反応式
[OH:1][CH2:2][C@H:3]([CH3:31])[O:4][C:5]1[CH:6]=[C:7]([CH:20]=[C:21]([C:23]([NH:25][C:26]2[CH:30]=[CH:29][NH:28][N:27]=2)=[O:24])[CH:22]=1)[O:8][C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15]CC)=[O:14])=[CH:11][CH:10]=1.[OH-].[Na+]>C1COCC1.O>[OH:1][CH2:2][C@H:3]([CH3:31])[O:4][C:5]1[CH:6]=[C:7]([CH:20]=[C:21]([C:23]([NH:25][C:26]2[CH:30]=[CH:29][NH:28][N:27]=2)=[O:24])[CH:22]=1)[O:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([OH:15])=[O:14])=[CH:18][CH:19]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 178469074HCID 178469074、化合物

生成物 1

HCID 178461815HCID 178461815、化合物収率 86.8%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of ethyl 4-{3-[(1S)-2-hydroxy-1-methylethoxy]-5-[(1H-pyrazol-3-ylamino)carbonyl]phenoxy}benzoate (175 mg, 0.4 mmol) in THF (5 mL) and water (1 mL) was treated with 1N sodium hydroxide solution (3 mL) and the reaction stirred at RT for 16 hours. On completion, the solvent was removed in vacuo and 1N citric acid added until pH 3-4. The white precipitate was collected by filtration and dried in vacuo to give the desired product as a white solid (138 mg, 85%).

後処理

  1. customOn completion, the solvent was removed in vacuo and 1N citric acid
  2. additionadded until pH 3-4
  3. filtrationThe white precipitate was collected by filtration
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-f71922eafb5c4170ae05152f347a6481
出典データセット
uspto-grants-2010_06
特許番号
US07745475B2

関連ノート

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