Sodium Thiosulfate → HCID 178469074、化合物

反応式

C[Si](I)(C)C.[CH2:6]([O:8][C:9]([C:11]1[CH:44]=[CH:43][C:14]([O:15][C:16]2[CH:17]=[C:18]([CH:34]=[C:35]([O:37][C@@H:38]([CH3:42])[CH2:39][O:40]C)[CH:36]=2)[C:19]([NH:21][C:22]2[CH:26]=[CH:25][N:24](C(OC(C)(C)C)=O)[N:23]=2)=[O:20])=[CH:13][CH:12]=1)=[O:10])[CH3:7].S([O-])([O-])(=O)=S.[Na+].[Na+]>C(#N)C>[OH:40][CH2:39][C@H:38]([CH3:42])[O:37][C:35]1[CH:36]=[C:16]([CH:17]=[C:18]([C:19]([NH:21][C:22]2[CH:26]=[CH:25][NH:24][N:23]=2)=[O:20])[CH:34]=1)[O:15][C:14]1[CH:13]=[CH:12][C:11]([C:9]([O:8][CH2:6][CH3:7])=[O:10])=[CH:44][CH:43]=1

参加物

実験手順

Trimethylsilyl iodide (0.27 mL) was added dropwise under argon to a solution of tert-butyl 3-({3-[4-(ethoxycarbonyl)phenoxy]-5-[(1S)-2-methoxy-1-methylethoxy]benzoyl}amino)-1H-pyrazole-1-carboxylate (167 mg, 0.38 mmol) in acetonitrile (5 mL) and stirred at ambient temperature for 16 hours. Sodium thiosulfate solution was added to quench the reaction and the reaction mixture was extracted into ethyl acetate (3×25 mL). Organic phases were combined and dried (MgSO4) and the filtrate was concentrated in vacuo to give a clear oil (180 mg), which was not purified further.