Borane → 2-((1S)-6-Bromo-3,4-dihydro-1H-2-benzopyran-1-yl)ethanol
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[C@H:10]([CH2:11][C:12](O)=[O:13])[O:9][CH2:8][CH2:7][C:6]=2[CH:15]=1.B.C(=O)([O-])[O-].[Na+].[Na+]>C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[C@H:10]([CH2:11][CH2:12][OH:13])[O:9][CH2:8][CH2:7][C:6]=2[CH:15]=1参加物
5
実験手順
To a solution of 2-((1S)-6-bromo-3,4-dihydro-1H-2-benzopyran-1-yl)acetic acid (21.3 g, 78.6 mmol) in anhydrous THF (65 mL) under an atmosphere of nitrogen and cooled to 0° C., was added dropwise borane.THF complex in THF (1M) (94 mL, 94 mmol). After stirring for 1 h between 0 and 10° C., the reaction mixture was treated with aqueous sodium carbonate then extracted into toluene. The organic layer was washed with dilute aqueous hydrochloric acid, then concentrated in vacuo to give the title compound as a white solid.
後処理
- extractionthen extracted into toluene
- washThe organic layer was washed with dilute aqueous hydrochloric acid
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-c2052c3b95db415d840ea13208e9a876
- 出典データセット
- uspto-grants-2008_02
- 特許番号
- US07335660B2
反応ノート
読み込み中…