4-Fluorobenzenesulfonyl chloride → Azetidine, 1-[(4-fluorophenyl)sulfonyl]-
反応式
[NH:1]1[CH2:4][CH2:3][CH2:2]1.[F:5][C:6]1[CH:11]=[CH:10][C:9]([S:12](Cl)(=[O:14])=[O:13])=[CH:8][CH:7]=1>C1COCC1>[F:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([N:1]2[CH2:4][CH2:3][CH2:2]2)(=[O:14])=[O:13])=[CH:8][CH:7]=1参加物
4
実験手順
Azetidine (0.25 g, 4.35 mmol) was added to a solution of sodium hexamethyldisilylazide (0.85 g, 4.6 mmol) in THF (10 mL) at 0° C. and reaction mixture stirred for 10 minutes. 4-fluorobenzenesulfonyl chloride (0.85 g, 4.35 mmol) was subsequently added and the reaction mixture was allowed to warm up to ambient temperature overnight. The reaction mixture was concentrated in vacuo and the residue taken up in ethyl acetate and water. The organic layer was separated and then dried (MgSO4), filtered and evaporated to give a waxy, yellow solid (75 mg).
後処理
- customreaction mixture
- concentrationThe reaction mixture was concentrated in vacuo
- customThe organic layer was separated
- dry with materialdried (MgSO4)
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-c32ba789be974ba99759bf5cf8743db1
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745475B2
反応ノート
読み込み中…