Trimethylamine → N-(2,4,4-trimethylcyclopenten-1-yl)-N-methyl-alpha-chloroacetamide

HRID 2058939

反応式

CC1(C)CC(C)CC1=O.CC1CC(C)(C)CC1=O.S([O-])([O-])(=O)=O.[NH4+].[NH4+].CN.ClCC(Cl)=O.CN(C)C.[CH3:37][C:38]1([CH3:50])[CH2:42][CH:41]([CH3:43])[C:40]([N:44]([CH3:49])[C:45](=[O:48])[CH2:46][Cl:47])=[CH:39]1.CC1CC(C)(C)C(N(C)C(=O)CCl)=C1>C1C=CC=CC=1>[CH3:43][C:41]1[CH2:42][C:38]([CH3:37])([CH3:50])[CH2:39][C:40]=1[N:44]([CH3:49])[C:45](=[O:48])[CH2:46][Cl:47]

参加物

実験手順

By the same procedure as in Example 1 using a mixture comprising 2,2,4-trimethylcyclopentanone and 2,4,4-trimethylcyclopentanone (about 1:1) (25.2 parts by weight) in 150 milliliters of benzene, one part by weight of ammonium sulfate and 6.2 parts by weight of methylamine, further reacted with 22.6 parts by weight of chloroacetyl chloride and 24.6 parts by weight of trimethylamine, a mixture of isomers consisting of N-(3,3,5-trimethylcyclopenten-1-yl)-N-methyl-α-chloroacetamide, N-(3,5,5-trimethylcyclopenten-1-yl)-N-methyl-α-chloroacetamide, and N-(2,4,4-trimethylcyclopenten-1-yl)-N-methyl-α-chloroacetamide was obtained. The yield of partially crystalline dark brown product amounted to 33 parts by weight. The molecular weight was determined to be 198 (215). The content of organically combined chlorine was 17.5% (16.5%). The nitrogen content was 6.3% (6.5%).

後処理

additiona mixture of isomers

出典と根拠

ORDレコード: ord-92838ca964e34dc0a04d5dabd5b80fcc
出典データセット: uspto-grants-1982_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04319918

反応式

参加物

反応物 8

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

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