Hydrazine hydrate (1:1) → 2371-31-5

HRID 2061406

反応式

HRID 2061406 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([O:12]CC)=O)=[CH:4][CH:3]=1.O.[NH2:16][NH2:17]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([NH:16][NH2:17])=[O:12])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 302644Glycine, N-(4-chlorophenyl)-, ethyl ester

生成物 1

HCID 3026472371-31-5収率 59%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl 2-(4-chlorophenylamino)acetate (A) (25.6 g, 120 mmol) and hydrazine monohydrate (7.0 mL, 144 mmol) were heated to reflux in ethanol (120 mL) for 22 hours. After concentration in vacuo, the solid obtained was recrystallised from ethanol to yield the title compound (14.0 g, 59%) as a pale brown powder. 1H NMR (400 MHz, CDCl3) δ 3.85 (2H, d), 4.18 (2H, br), 6.53 (2H, d), 7.16 (2H, d), 7.60 (1H, br).

後処理

  1. concentrationAfter concentration in vacuo
  2. customthe solid obtained
  3. customwas recrystallised from ethanol

出典と根拠

ORDレコード
ord-4de39e719876495c897ec661c521281c
出典データセット
uspto-grants-2012_10
特許番号
US08283351B2

関連ノート

読み込み中…