1-(4-Benzyl-piperazin-1-yl)-2-hydroxy-4-methyl-pentan-1-one → (R)-2-hydroxy-4-methyl-1-(piperazin-1-yl)pentan-1-one

HRID 2062183

反応式

HRID 2062183 の反応式
C([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:21])[CH:15]([OH:20])[CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[OH:20][C@H:15]([CH2:16][CH:17]([CH3:19])[CH3:18])[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:21]

参加物

4

反応物 1

HCID 670984871-(4-Benzyl-piperazin-1-yl)-2-hydroxy-4-methyl-pentan-1-one

生成物 1

HCID 59216548(R)-2-hydroxy-4-methyl-1-(piperazin-1-yl)pentan-1-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 1-(4-benzyl-piperazin-1-yl)-2-hydroxy-4-methyl-pentan-1-one (132 g) in methanol (1 L) was added Pd/C (20 g, 10% weight Pd on carbon). The reaction mixture was stirred at room temperature overnight under an atmosphere of hydrogen. The reaction mixture was filtered through Celite, and the solvent was removed in vacuo. (R)-2-Hydroxy-4-methyl-1-piperazin-1-yl-pentan-1-one was obtained as an oil (68 g, 74%).

後処理

  1. filtrationThe reaction mixture was filtered through Celite
  2. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-ffa6fa441c4c4736b443fec6ac8deda4
出典データセット
uspto-grants-2012_10
特許番号
US08283354B2

関連ノート

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