Hydrochloric Acid → 4-(1-Hydroxy-2-phenylethyl)cyclohexanone

HRID 2063717ノート

反応式

HRID 2063717 の反応式
Cl.[O:2]1[C:6]2([CH2:11][CH2:10][CH:9]([CH:12]([OH:20])[CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:8][CH2:7]2)OCC1.[OH-].[Na+]>O1CCCC1>[OH:20][CH:12]([CH:9]1[CH2:8][CH2:7][C:6](=[O:2])[CH2:11][CH2:10]1)[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 668872701-(1,4-Dioxaspiro[4.5]dec-8-yl)-2-phenylethanol

生成物 1

HCID 214336324-(1-Hydroxy-2-phenylethyl)cyclohexanone

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
50 °C

実験手順

2 M hydrochloric acid (30 ml) was added to a solution of 1-(1,4-dioxaspiro[4.5]dec-8-yl)-2-phenylethanol (2.98 g, 11.3 mmol) in tetrahydrofuran (30 ml). The solution was stirred at 50° C. overnight. The mixture was rendered alkaline with 4 M sodium hydroxide solution, the phases were separated and the aqueous phase was extracted with methylene chloride (3×20 ml). The combined organic phases were dried with sodium sulfate and concentrated i. vac.

後処理

  1. customthe phases were separated
  2. extractionthe aqueous phase was extracted with methylene chloride (3×20 ml)
  3. dry with materialThe combined organic phases were dried with sodium sulfate
  4. concentrationconcentrated i

出典と根拠

ORDレコード
ord-713d35b5ac0643b5a7e4359842bfb1ab
出典データセット
uspto-grants-2012_10
特許番号
US08288406B2

反応ノート

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