Lithium Hydroxide → 2-(2-Hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-6-methylamino-3,4-dihydro-2H-isoquinolin-1-one

反応式

[CH3:1][N:2]1[CH:7]=[C:6](B2OC(C)(C)C(C)(C)O2)[CH:5]=[C:4]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)=[O:25])=[CH:20][N:19]=2)[C:3]1=[O:32].Br[C:34]1[CH:44]=[CH:43][CH:42]=[C:41]([N:45]2[CH2:54][CH2:53][C:52]3[C:47](=[CH:48][CH:49]=[C:50]([NH:55][CH3:56])[CH:51]=3)[C:46]2=[O:57])[C:35]=1[CH2:36][O:37]C(=O)C.P([O-])([O-])([O-])=O.[K+].[K+].[K+].[OH-].[Li+]>>[OH:37][CH2:36][C:35]1[C:34]([C:6]2[CH:5]=[C:4]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]([N:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)=[O:25])=[CH:20][N:19]=3)[C:3](=[O:32])[N:2]([CH3:1])[CH:7]=2)=[CH:44][CH:43]=[CH:42][C:41]=1[N:45]1[CH2:54][CH2:53][C:52]2[C:47](=[CH:48][CH:49]=[C:50]([NH:55][CH3:56])[CH:51]=2)[C:46]1=[O:57]