Hydroxyamine hydrochloride → 1-(5-(Prop-1-en-2-yl)pyridin-3-yl)ethanone oxime
反応式
[CH2:1]=[C:2]([C:4]1[CH:5]=[C:6]([C:10](=O)[CH3:11])[CH:7]=[N:8][CH:9]=1)[CH3:3].[NH2:13][OH:14].Cl>CCO.O.[OH-].[Na+]>[CH2:1]=[C:2]([C:4]1[CH:5]=[C:6]([C:10](=[N:13][OH:14])[CH3:11])[CH:7]=[N:8][CH:9]=1)[CH3:3]参加物
6
実験手順
To a stirred solution of 1-(5-(prop-1-en-2-yl)pyridin-3-yl)ethanone (460 mg, 2.86 mmol) in 95% EtOH was added a solution of NH2OH.HCl (1.19 g, 17.14 mmol) in a mixture of water (5.8 mL) and 10% NaOH (5.8 mL) and refluxed for 2.5 h. All solvent was removed. The residue was dissolved in CHCl3, washed with water, dried with Na2SO4 and concentrated under reduced pressure to yield 400 mg of crude 1-(5-(prop-1-en-2-yl)pyridin-3-yl)ethanone oxime.
後処理
- temperaturerefluxed for 2.5 h
- customAll solvent was removed
- dissolutionThe residue was dissolved in CHCl3
- washwashed with water
- dry with materialdried with Na2SO4
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-e147ab0d50b442a9884cffd846ce1bdc
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08299267B2
反応ノート
読み込み中…