Ethanol → 3-Methyl-8-oximino-5,6,7,8-tetrahydroquinoline
反応式
[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[C:6](=O)[CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=1.Cl.[NH2:14][OH:15].[OH-].[Na+].C(O)C>O>[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[C:6](=[N:14][OH:15])[CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=1参加物
6
実験手順
The quinoline (30g), hydroxylamine hydrochloride (14g), sodium hydroxide (9g), ethanol (165ml) and water (65ml) were stirred and refluxed for 2 hours. Water (100ml) was added and the product was allowed to crystallise overnight. The crystals were removed by filtration and washed with water and dried to give 3-methyl-8-oximino-5,6,7,8-tetrahydroquinoline (27.5g) mp 188° C.
後処理
- temperaturerefluxed for 2 hours
- customto crystallise overnight
- customThe crystals were removed by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-bad60323c8ff471fa2c71be304bfaeb8
- 出典データセット
- uspto-grants-1977_09
- 特許番号
- US04048175
反応ノート
読み込み中…