Hydrochloric Acid → HCID 131710913、化合物

HRID 2072488ノート

反応式

HRID 2072488 の反応式
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[CH2:8][CH2:7][CH2:6]2.[ClH:16].[CH3:17][NH:18][CH3:19].[CH2:20]=O.Cl>CC(C)=O.C(O)C>[ClH:16].[CH3:17][N:18]([CH2:20][CH:8]1[CH2:7][CH2:6][C:5]2[C:10](=[CH:11][CH:12]=[C:3]([C:2]([F:14])([F:15])[F:1])[CH:4]=2)[C:9]1=[O:13])[CH3:19]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 712Formaldehyde2 回HCID 10473Dimethylamine, hydrochlorideHCID 149151176-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one

生成物 1

HCID 131710913HCID 131710913、化合物収率 77.3%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 702Ethanol溶媒

実験手順

A mixture of 6-(trifluoromethyl)-1-tetralone (0.90 g), dimethylamine hydrochloride (0.42 g), paraformaldehyde (0.16 g), and 95% ethanol (2 ml) containing concentrated hydrogen chloride (0.02 ml) is heated on a steam bath for 1 1/2 hours. The reaction mixture soon becomes homogeneous and the paraformaldehyde dissolves. The warm solution is diluted with acetone (15 ml) and cooled to yield the title compound as white needles (1.0 g) melting point 137°-138° C.

後処理

  1. temperatureis heated on a steam bath for 1 1/2 hours
  2. temperaturecooled

出典と根拠

ORDレコード
ord-d1e58b26508347cbbd8b91c582559e2c
出典データセット
uspto-grants-1977_09
特許番号
US04051248

反応ノート

読み込み中…