Ethanol → HCID 178487786、化合物

HRID 2073775

反応式

HRID 2073775 の反応式
Cl[C:2]1[C:11]([C:12]#[N:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7](OC)[CH:8]=2)[N:3]=1.[OH2:16].[NH2:17][NH2:18].[CH2:19](O)C>>[CH3:19][O:16][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]1[NH:17][N:18]=[C:12]([NH2:13])[C:11]1=[CH:10]2

参加物

4

反応物 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 8656122-Chloro-6-methoxyquinoline-3-carbonitrile

生成物 1

HCID 178487786HCID 178487786、化合物

反応条件

温度
0 °C

実験手順

To a stirred suspension of 14.7 g 2-chloro-6-methoxy-3-quinolinecarbonitrile in 465 ml absolute ethanol was added 17 ml of hydrazine hydrate. The mixture was stirred at reflux for 24 hours and then cooled to 0° C. The resulting solid product was collected by filtration and boiled with 200 ml water to remove any hydrazine dihydrochloride present. The resulting material was filtered and dried in vacuo (90° C.), and recrystallized from 300 ml dimethylformamide to give 12.3 g 6-methoxy-1H-pyrazolo[3,4-b]quinolin-3-amine as a bright-yellow solid, m.p. >300° C.

後処理

  1. temperatureat reflux for 24 hours
  2. filtrationThe resulting solid product was collected by filtration
  3. customto remove any hydrazine dihydrochloride present
  4. filtrationThe resulting material was filtered
  5. customdried in vacuo (90° C.)
  6. customrecrystallized from 300 ml dimethylformamide

出典と根拠

ORDレコード
ord-e856b0b942ca4b188d232eb02f3ec0a3
出典データセット
uspto-grants-1990_04
特許番号
US04920128

関連ノート

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