Triethylamine → Ethyl 2-(3-(2-(3-(2-quinolinylmethyloxy)phenyl)-2-(carbethoxyethylthio)ethyl)phenoxy)acetate

HRID 2073908ノート

反応式

HRID 2073908 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:19](O)[CH2:20][C:21]2[CH:22]=[C:23]([CH:31]=[CH:32][CH:33]=2)[O:24][CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])[CH:16]=[CH:17][CH:18]=1.O=S(Cl)Cl.[SH:39][CH2:40][CH2:41][C:42]([O:44][CH2:45][CH3:46])=[O:43].C(N(CC)CC)C>C(Cl)Cl>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:19]([S:39][CH2:40][CH2:41][C:42]([O:44][CH2:45][CH3:46])=[O:43])[CH2:20][C:21]2[CH:22]=[C:23]([CH:31]=[CH:32][CH:33]=2)[O:24][CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])[CH:16]=[CH:17][CH:18]=1

参加物

6

反応物 4

HCID 8471TriethylamineHCID 21625Ethyl 3-mercaptopropionateHCID 24386Thionyl ChlorideHCID 14774138Ethyl 2-(3-(2-(3-(2-quinolinylmethyloxy)phenyl)-2-hydroxyethyl)phenoxy)acetate

生成物 1

HCID 14774139Ethyl 2-(3-(2-(3-(2-quinolinylmethyloxy)phenyl)-2-(carbethoxyethylthio)ethyl)phenoxy)acetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The product obtained from Step C in 50 mL of CH2Cl2 is treated with 2 mL of SOCl2. The reaction mixture is stirred at room temperature for 2 hr. and then evaporated to dryness. The crude product thus obtained in 20 mL of CH2Cl2 is treated with ethyl 3-mercaptopropionate and triethylamine (1:1) for 16 hr. at room temperature. After evaporation of solvent, the crude product is purified by flash column chromatography to obtain ethyl 2-(3-(2-(3-(2-quinolinylmethyloxy)phenyl)-2-(carbethoxyethylthio)ethyl)phenoxy)acetate.

後処理

  1. customand then evaporated to dryness
  2. customThe crude product thus obtained in 20 mL of CH2Cl2
  3. customat room temperature
  4. customAfter evaporation of solvent
  5. customthe crude product is purified by flash column chromatography

出典と根拠

ORDレコード
ord-3f407f963e5e4525a20197cbeb3b659a
出典データセット
uspto-grants-1990_04
特許番号
US04920131

反応ノート

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