Ammonium formate → (Octahydropyrrolo[1,2-a]pyrazin-8a-yl)methanol
反応式
C1(C[N:8]2[CH2:13][CH2:12][N:11]3[CH2:14][CH2:15][CH2:16][C:10]3([CH2:17][OH:18])[CH2:9]2)C=CC=CC=1.C([O-])=O.[NH4+]>CO.[Pd]>[CH2:9]1[NH:8][CH2:13][CH2:12][N:11]2[CH2:14][CH2:15][CH2:16][C:10]12[CH2:17][OH:18]参加物
5
実験手順
To a solution of [2-(phenylmethyl)hexahydropyrrolo[1,2-a]pyrazin-8a(6H)-yl]methanol (D66, 180 mg) in anhydrous methanol (5 mL) under a Nitrogen atmosphere at rt, ammonium formate (475 mg) and palladium (10% on carbon, 13 mg) were added. The resulting suspension was heated at reflux temperature for 3.5 hours, then allowed to cool to r.t. and filtered over Celite. The organic extract was dried and concentrated in vacuo to give the desired compound (120 mg) as orange waxy solid.
後処理
- temperatureThe resulting suspension was heated
- temperatureat reflux temperature for 3.5 hours
- filtrationfiltered over Celite
- extractionThe organic extract
- customwas dried
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-086a3a9d19d54652983aa6afadb733e3
- 出典データセット
- uspto-grants-2011_04
- 特許番号
- US07919491B2
反応ノート
読み込み中…