Tetrahydrofuran → Ethyl 2-oxo-2,3-dihydrobenzo[d]oxazole-6-carboxylate
反応式
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[OH:12].[C:13](N1C=CN=C1)(N1C=CN=C1)=[O:14].[CH2:25]1COCC1>>[O:14]=[C:13]1[NH:1][C:2]2[CH:11]=[CH:10][C:5]([C:6]([O:8][CH2:9][CH3:25])=[O:7])=[CH:4][C:3]=2[O:12]1参加物
4
実験手順
Methyl 4-amino-3-hydroxybenzoate (1.23 g, 7.36 mmol) (commercially available from Pfaltz & Bauer Chemicals Catalog (Order Number A22677)) and 1,1′-carbonyldiimidazole (1.19 g, 7.36 mmol) in 20 mL THF were heated by microwave at 100° C. for 10 minutes. The reaction mixture was used directly for next step. LCMS (API-ES) m/z: 194 (M+H+).
出典と根拠
- ORDレコード
- ord-4fb885a549b0401d84650fbea183dcfa
- 出典データセット
- uspto-grants-2011_04
- 特許番号
- US07919504B2
反応ノート
読み込み中…