Hydroxyamine hydrochloride → 4-[3-(2-Amino-4-phenyl-quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile

HRID 2075664ノート

反応式

HRID 2075664 の反応式
C(=[N:14][C:15]1[CH:24]=[C:23]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:22]2[C:17](=[CH:18][C:19]([S:31][C:32]3[CH:33]=[C:34]([C:38]4([C:44]#[N:45])[CH2:43][CH2:42][O:41][CH2:40][CH2:39]4)[CH:35]=[CH:36][CH:37]=3)=[CH:20][CH:21]=2)[N:16]=1)(C1C=CC=CC=1)C1C=CC=CC=1.Cl.NO.C([O-])(=O)C.[K+]>CO>[NH2:14][C:15]1[CH:24]=[C:23]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:22]2[C:17](=[CH:18][C:19]([S:31][C:32]3[CH:33]=[C:34]([C:38]4([C:44]#[N:45])[CH2:39][CH2:40][O:41][CH2:42][CH2:43]4)[CH:35]=[CH:36][CH:37]=3)=[CH:20][CH:21]=2)[N:16]=1

参加物

5

反応物 3

HCID 443297Hydroxyamine hydrochlorideHCID 517044Potassium AcetateHCID 866138274-{3-[2-(Benzhydrylidene-amino)-4-phenyl-quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile

生成物 1

HCID 670910914-[3-(2-Amino-4-phenyl-quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1s (110 mg, 0.18 mmol), hydroxylamine hydrochloride (25 mg, 0.36 mmol), and potassium acetate (44 mg, 0.45 mmol) were dissolved in MeOH (10 mL) and stirred at room temperature for 30 minutes. The reaction was concentrated and diluted with EtOAc and water. The aqueous layer was extracted with EtOAc, and the combined organic layers were dried over MgSO4, filtered, and concentrated to give 1t.

後処理

  1. concentrationThe reaction was concentrated
  2. additiondiluted with EtOAc and water
  3. extractionThe aqueous layer was extracted with EtOAc
  4. dry with materialthe combined organic layers were dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-6326624228f1468b82dae49d1326d9be
出典データセット
uspto-grants-2011_04
特許番号
US07919621B2

反応ノート

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