Hydroxyamine hydrochloride → 4-{3-[2-Amino-4-(4-fluoro-phenyl)-quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile

HRID 2075676ノート

反応式

HRID 2075676 の反応式
C(=[N:14][C:15]1[CH:24]=[C:23]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[C:22]2[C:17](=[CH:18][C:19]([S:32][C:33]3[CH:34]=[C:35]([C:39]4([C:45]#[N:46])[CH2:44][CH2:43][O:42][CH2:41][CH2:40]4)[CH:36]=[CH:37][CH:38]=3)=[CH:20][CH:21]=2)[N:16]=1)(C1C=CC=CC=1)C1C=CC=CC=1.Cl.NO.C([O-])(=O)C.[K+]>CO>[NH2:14][C:15]1[CH:24]=[C:23]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[C:22]2[C:17](=[CH:18][C:19]([S:32][C:33]3[CH:34]=[C:35]([C:39]4([C:45]#[N:46])[CH2:40][CH2:41][O:42][CH2:43][CH2:44]4)[CH:36]=[CH:37][CH:38]=3)=[CH:20][CH:21]=2)[N:16]=1

参加物

5

反応物 3

HCID 443297Hydroxyamine hydrochlorideHCID 517044Potassium AcetateHCID 866138284-{3-[2-(Benzhydrylidene-amino)-4-(4-fluoro-phenyl)-quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile

生成物 1

HCID 670907114-{3-[2-Amino-4-(4-fluoro-phenyl)-quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3d (300 mg, 0.48 mmol), hydroxylamine hydrochloride (67 mg, 0.97 mmol), and potassium acetate (92 mg, 0.97 mmol) was dissolved in MeOH (10 mL) and stirred overnight at room temperature. The reaction was concentrated and purified by silica gel chromatography (30% EtOAc in hexanes) to obtain the desired product, 3e.

後処理

  1. concentrationThe reaction was concentrated
  2. custompurified by silica gel chromatography (30% EtOAc in hexanes)

出典と根拠

ORDレコード
ord-4854c5b9dc39445192c0f643efdcd576
出典データセット
uspto-grants-2011_04
特許番号
US07919621B2

反応ノート

読み込み中…