Methylamine → 5-Bromo-N-methyl-3-nitropyridin-2-amine

HRID 2077537

反応式

HRID 2077537 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[C:5](Cl)=[N:6][CH:7]=1.O1CCCC1.[CH3:17][NH2:18]>CO>[Br:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[C:5]([NH:18][CH3:17])=[N:6][CH:7]=1

参加物

5

反応物 3

HCID 6329MethylamineHCID 8028TetrahydrofuranHCID 70194125-Bromo-2-chloro-3-nitropyridine

生成物 1

HCID 108681495-Bromo-N-methyl-3-nitropyridin-2-amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

5-bromo-2-chloro-3-nitropyridine (456 mg, 1920 μmol) was dissolved in MeOH (6.0 ml) and methylamine, 2.0 M solution in tetrahydrofuran (2.5 ml, 5.0 mmol) was added. The reaction was stirred at room temperature for 6 hours, allowed to stand at room temperature overnight, and then concentrated. material was taken directly to the next step.

後処理

  1. waitto stand at room temperature overnight
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-477fb39ca8fe4324914ee8e5e98c1828
出典データセット
uspto-grants-2011_04
特許番号
US07928140B2

関連ノート

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