Methyl iodide → Tert-butyl tert-butyl(2-((2-chlorophenyl)(methyl)carbamoyl)-4,5-dihydropyrido[4,3-b]thieno[2,3-d]oxepin-8-yl)carbamate
反応式
[C:1]([N:5]([C:13]1[N:23]=[CH:22][C:21]2[C:20]3[S:24][C:25]([C:27](=[O:36])[NH:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=4[Cl:35])=[CH:26][C:19]=3[CH2:18][CH2:17][O:16][C:15]=2[CH:14]=1)[C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])([CH3:4])([CH3:3])[CH3:2].[CH3:37]I.[H-].[Na+]>>[C:1]([N:5]([C:13]1[N:23]=[CH:22][C:21]2[C:20]3[S:24][C:25]([C:27](=[O:36])[N:28]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=4[Cl:35])[CH3:37])=[CH:26][C:19]=3[CH2:18][CH2:17][O:16][C:15]=2[CH:14]=1)[C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])([CH3:2])([CH3:3])[CH3:4]参加物
4
反応物 3
生成物 1
実験手順
Following Scheme 4, tert-butyl tert-butyl(2-(2-chlorophenylcarbamoyl)-4,5-dihydropyrido[4,3-b]thieno[2,3-d]oxepin-8-yl)carbamate, methyl iodide and sodium hydride were reacted to give tert-butyl tert-butyl(2-((2-chlorophenyl)(methyl)carbamoyl)-4,5-dihydropyrido[4,3-b]thieno[2,3-d]oxepin-8-yl)carbamate (78%). MS: (ESI+) 542.3