Ethyl Acetate → 2-(3-(4-bromo-2-(trifluoromethyl)phenoxy)propoxy)tetrahydro-2H-pyran

HRID 2079528ノート

反応式

HRID 2079528 の反応式
[Br:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][CH2:8][CH2:9][OH:10])=[C:4]([C:13]([F:16])([F:15])[F:14])[CH:3]=1.O.[C:18]1(C)C=[CH:22][C:21](S(O)(=O)=O)=[CH:20][CH:19]=1.C(OCC)(=[O:31])C>C1COCC1.C(=O)([O-])[O-].[Na+].[Na+]>[Br:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][CH2:8][CH2:9][O:10][CH:22]2[CH2:21][CH2:20][CH2:19][CH2:18][O:31]2)=[C:4]([C:13]([F:14])([F:15])[F:16])[CH:3]=1

参加物

6

反応物 3

HCID 8857Ethyl AcetateHCID 521998p-Toluenesulfonic acid monohydrateHCID 576575913-(4-Bromo-2-(trifluoromethyl)-phenoxy)propan-1-ol

生成物 1

HCID 576575642-(3-(4-bromo-2-(trifluoromethyl)phenoxy)propoxy)tetrahydro-2H-pyran

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 10340Sodium Carbonate溶媒

実験手順

A mixture of 3-(4-bromo-2-(trifluoromethyl)-phenoxy)propan-1-ol (12 g), 3,4-dihydro-2H-puran (6.75 g) and p-toluenesulfonic acid hydrate (0.76 g) in THF (100 ml) was stirred at room temperature for 1 hour then diluted with 10% sodium carbonate (50 ml) and extrated with ethyl acetate (2×150 ml). Organic layer was then dried over sodium sulphate, solvent removed under reduced pressure to give expected product (15 g).

後処理

  1. dry with materialOrganic layer was then dried over sodium sulphate, solvent
  2. customremoved under reduced pressure

出典と根拠

ORDレコード
ord-265484f509b847db9ab02dee04ada42b
出典データセット
uspto-grants-2011_04
特許番号
US07932251B2

反応ノート

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