Hydrogen Bromide → 2-Amino-5-bromo-3-fluorobenzoic acid

HRID 2079623

反応式

HRID 2079623 の反応式
[NH2:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br.Br>C(Cl)(Cl)Cl>[NH2:1][C:2]1[C:10]([F:11])=[CH:9][C:8]([Br:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

参加物

5

反応物 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 5864082-Amino-3-fluorobenzoic acid

生成物 1

HCID 404245972-Amino-5-bromo-3-fluorobenzoic acid収率 95%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

To a suspension of 2-amino-3-fluorobenzoic acid (5 g, 32.2 mmol) in chloroform (200 mL) was added dropwise bromine (1.1 equiv.) in chloroform (125 mL) solution. The mixture was stirred at room temperature for 16 hrs. The resulting white solid was collected by filtration and washed thoroughly with methylene chloride until the filtrate was colorless. The solid was air-dried to give 9.6 g of white powder as HBr salt of 2-amino-5-bromo-3-fluorobenzoic acid (95% yield). ES/MS m/z 234/236 (MH+).

後処理

  1. filtrationThe resulting white solid was collected by filtration
  2. washwashed thoroughly with methylene chloride until the filtrate
  3. customThe solid was air-dried

出典と根拠

ORDレコード
ord-465e8168695f4c588921e7bc7792097b
出典データセット
uspto-grants-2011_04
特許番号
US07932262B2

関連ノート

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