Hydrogen Bromide → 2-Amino-5-bromo-3-chlorobenzoic acid

HRID 2079625

反応式

HRID 2079625 の反応式
[NH2:1][C:2]1[C:10]([Cl:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br.Br>C(Cl)(Cl)Cl>[NH2:1][C:2]1[C:10]([Cl:11])=[CH:9][C:8]([Br:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

参加物

5

反応物 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 808072-Amino-3-chlorobenzoic acid

生成物 1

HCID 8279792-Amino-5-bromo-3-chlorobenzoic acid収率 87%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

To a suspension of 2-amino-3-chlorobenzoic acid (2 g, 11.6 mmol) in chloroform (120 mL) was added dropwise bromine (1.1 equiv.) in chloroform (12 mL) solution. The mixture was stirred at room temperature for 16 hrs. The resulting white solid was collected by filtration and washed thoroughly with methylene chloride until the filtrate was colorless. The solid was air-dried to give 3.35 g of white powder as HBr salt of 2-amino-5-bromo-3-chlorobenzoic acid (87% yield). ES/MS m/z 250/252 (MH+).

後処理

  1. filtrationThe resulting white solid was collected by filtration
  2. washwashed thoroughly with methylene chloride until the filtrate
  3. customThe solid was air-dried

出典と根拠

ORDレコード
ord-3f417d96222c474b91be7cd3eaffa9f3
出典データセット
uspto-grants-2011_04
特許番号
US07932262B2

関連ノート

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