2-Nitro-4-trifluoromethylanisole → 2-Methoxy-5-(trifluoromethyl)aniline

HRID 2079681

反応式

HRID 2079681 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][C:4]=1[N+:13]([O-])=O>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:10])([F:11])[F:12])=[CH:5][C:4]=1[NH2:13]

参加物

4

反応物 1

HCID 967482-Nitro-4-trifluoromethylanisole

生成物 1

HCID 6006372-Methoxy-5-(trifluoromethyl)aniline収率 99%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 4-methoxy-3-nitrobenzotrifluoride and 10% of 10% Pd/C in methanol was stirred under H2 atmosphere overnight at room temperature. The reaction mixture was filtered through celite, concentrated and dried under vacuum to provide product as an off white solid in 99% yield. ES/MS m/z 192.1 (MH+).

後処理

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationconcentrated
  3. customdried under vacuum
  4. customto provide product as an off white solid in 99% yield

出典と根拠

ORDレコード
ord-0e11a43a96194bd6b45518dc8d910a74
出典データセット
uspto-grants-2011_04
特許番号
US07932262B2

関連ノート

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