4-(1-isopropyl-6-nitro-1H-indol-3-yl)-benzonitrile → 4-(6-amino-1-isopropyl-1H-indol-3-yl)-benzonitrile

HRID 2079882

反応式

HRID 2079882 の反応式
[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([N+:13]([O-])=O)[CH:11]=2)[C:6]([C:16]2[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=2)=[CH:5]1)([CH3:3])[CH3:2].[H][H]>O1CCCC1.[Pt]=O>[NH2:13][C:10]1[CH:11]=[C:12]2[C:7]([C:6]([C:16]3[CH:17]=[CH:18][C:19]([C:20]#[N:21])=[CH:22][CH:23]=3)=[CH:5][N:4]2[CH:1]([CH3:2])[CH3:3])=[CH:8][CH:9]=1

参加物

5

反応物 2

HCID 574421944-(1-isopropyl-6-nitro-1H-indol-3-yl)-benzonitrileHCID 178418361HCID 178418361、化合物

生成物 1

HCID 574422014-(6-amino-1-isopropyl-1H-indol-3-yl)-benzonitrile収率 99.7%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 8028Tetrahydrofuran溶媒

実験手順

Method E Placc 4-(1-isopropyl-6-nitro-1H-indol-3-yl)-benzonitrile (4, R1=i-Pr, R3=4-benzonitrile) 250 mg, 0.82 mmol) in a 50 mL flask and add a suspension of platinum (II) oxide (16 mg) in tetrahydrofuran (9 mL). Place the reaction under 1 atmosphere of hydrogen and stir until the starting material is consumed. Filter through a celite pad and wash the pad with ethyl acetate (50 mL). Concentrate the combined filtrates to give 225.0 mg of the title compound (99%). LRMS (API ES+)=276.0 (M+H).

後処理

  1. customis consumed
  2. filtrationFilter through a celite pad
  3. washwash the pad with ethyl acetate (50 mL)
  4. concentrationConcentrate the combined filtrates

出典と根拠

ORDレコード
ord-91566e7c6935422598c04403973d2157
出典データセット
uspto-grants-2011_04
特許番号
US07932284B2

関連ノート

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