Acrylonitrile → 4-Cyano-2-diaminomethylene-butyric acid ethyl ester

HRID 2079945ノート

反応式

HRID 2079945 の反応式
Cl.[CH2:2]([O:4][C:5](=[O:10])[CH:6]=[C:7]([NH2:9])[NH2:8])[CH3:3].C(N(CC)CC)C.[C:18](#[N:21])[CH:19]=[CH2:20]>O1CCCC1>[CH2:2]([O:4][C:5](=[O:10])[C:6]([CH2:20][CH2:19][C:18]#[N:21])=[C:7]([NH2:9])[NH2:8])[CH3:3]

参加物

5

反応物 3

HCID 7855AcrylonitrileHCID 8471TriethylamineHCID 124946853,3-Diamino-acrylic acid ethyl ester hydrochloride

生成物 1

HCID 124949064-Cyano-2-diaminomethylene-butyric acid ethyl ester収率 25%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The resulting 3,3-diamino-acrylic acid ethyl ester hydrochloride (2.2 g, 13.2 mmol) was suspended in tetrahydrofuran (40 mL), triethylamine (2 mL, 14.3 mmol) and acrylonitrile (1.2 mL, 19.3 mmol) were added thereto, and the solution was refluxed for 6 hours. After the reaction was completed, the resulting triethylamine hydrochloride was filtered, and the filtrate was concentrated to obtain the title compound (0.6 g, 3.3 mmol, 25%).

後処理

  1. temperaturethe solution was refluxed for 6 hours
  2. filtrationthe resulting triethylamine hydrochloride was filtered
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-c7c9ccec28754008a4a0fb919cbcca90
出典データセット
uspto-grants-2011_04
特許番号
US07932272B2

反応ノート

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