Nitric Acid → HCID 57433540、化合物

HRID 2080665ノート

反応式

HRID 2080665 の反応式
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:15]=[C:14]([NH:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[O:18])[CH:13]=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9].C(=O)([O-])[O-].[Na+].[Na+]>O>[F:5][C:6]1[CH:15]=[C:14]([NH:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[O:18])[C:13]([N+:1]([O-:4])=[O:2])=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]

参加物

5

反応物 3

HCID 944Nitric AcidHCID 10340Sodium CarbonateHCID 57433539Methyl 2-fluoro-4-[(pyridine-2-carbonyl)amino]benzoate

生成物 1

HCID 57433540HCID 57433540、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

With cooling with ice, 110 ml of fuming nitric acid was gradually added to 27.7 g of methyl 2-fluoro-4-[(2-pyridinylcarbonyl)amino]benzoate, and stirred at room temperature for 1.5 hours. With cooling with ice, the reaction liquid was gradually added to a solution of sodium carbonate (138 g) in water (2000 ml), and the formed solid was taken out through filtration. This was dried under reduced pressure to obtain 27.5 g of the entitled compound as a yellow solid.

後処理

  1. temperatureWith cooling with ice
  2. customthe reaction liquid
  3. filtrationthe formed solid was taken out through filtration
  4. customThis was dried under reduced pressure

出典と根拠

ORDレコード
ord-870e307c5bb8410aaae104a10e2bf771
出典データセット
uspto-grants-2011_04
特許番号
US07932394B2

反応ノート

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