Methanol → {3-[6-(4-Aminomethyl-phenyl)-pyridin-2-yl]-propyl}-dipropyl-amine

HRID 2080806ノート

反応式

HRID 2080806 の反応式
CO.[CH2:3]([N:6]([CH2:34][CH2:35][CH3:36])[CH2:7][CH2:8][CH2:9][C:10]1[N:15]=[C:14]([C:16]2[CH:33]=[CH:32][C:19]([CH2:20][N:21]3C(=O)C4C(=CC=CC=4)C3=O)=[CH:18][CH:17]=2)[CH:13]=[CH:12][CH:11]=1)[CH2:4][CH3:5].O.NN>C(Cl)(Cl)Cl>[NH2:21][CH2:20][C:19]1[CH:32]=[CH:33][C:16]([C:14]2[N:15]=[C:10]([CH2:9][CH2:8][CH2:7][N:6]([CH2:34][CH2:35][CH3:36])[CH2:3][CH2:4][CH3:5])[CH:11]=[CH:12][CH:13]=2)=[CH:17][CH:18]=1

参加物

5

反応物 3

HCID 887MethanolHCID 24654Hydrazine hydrate (1:1)HCID 231554522-{4-[6-(3-Dipropylamino-propyl)-pyridin-2-yl]-benzyl}-isoindol-1,3-dione

生成物 1

HCID 23155536{3-[6-(4-Aminomethyl-phenyl)-pyridin-2-yl]-propyl}-dipropyl-amine収率 105.3%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

反応条件

温度
60 °C

実験手順

A methanol solution (2.0 ml) containing the compound (40.0 mg) obtained in Example 36-4 was added with hydrazine monohydrate (44 mg) and the whole was stirred at 60° C. for 1.5 hours, followed by distillating off the solvent. The residue was dissolved in chloroform and filtrated through Celite, the solvent was distilled off, thereby obtaining the subject compound (30.1 mg) as an amber liquid.

後処理

  1. filtrationfiltrated through Celite
  2. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-e296b3619ace4450931041a4571e2bfa
出典データセット
uspto-grants-2011_04
特許番号
US07932281B2

反応ノート

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