反応式
[CH3:1][N:2]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)C1(C#N)CCCC1.C1([Li])C=CC=CC=1.C(OCCCC)CCC.[BH4-].[Na+].[NH2:35][CH:36]([C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)[C:37]1(N(C)C)[CH2:41][CH2:40][CH2:39][CH2:38]1>C1COCC1.CO>[NH2:35][CH:36]([C:45]1[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=1)[C:37]1([CH2:1][NH:2][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:38][CH2:39][CH2:40][CH2:41]1参加物
8
反応物 5
生成物 1
試薬・触媒・溶媒 2
実験手順
The title compound (3.90 g; 47%) was prepared from 1-[methyl(phenylmethyl)amino]cyclopentanecarbonitrile D28 (6.0 g; 28 mmol) and phenyllithium in di-n-butylether (16.21 ml of 1.9M solution; 30.8 mmol) in THF (60 ml), followed by reaction with sodium borohydride (3.2 g; 84 mmol) in methanol (60 ml) in a similar manner to that described in D2. Mass Spectrum (Electrospray LC/MS), API+: Found 295 (MH+). C20H26N2 requires 294. Ret. time 2.12 min.
出典と根拠
- ORDレコード
- ord-1fb988fc9adb4ceeaad621b801b09955
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745642B2
関連ノート
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