Benzoyl chloride → 6-Methyl-2-phenyl-1,3-benzoxazole

HRID 2082914ノート

反応式

HRID 2082914 の反応式
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:10][C:11]1[CH:12]=[CH:13][C:14]([CH3:18])=[CH:15][C:16]=1O>N1C=CC=CC=1>[CH3:18][C:14]1[CH:13]=[CH:12][C:11]2[N:10]=[C:1]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[O:8][C:16]=2[CH:15]=1

参加物

4

反応物 2

HCID 7412Benzoyl chlorideHCID 760822-Amino-5-methylphenol

生成物 1

HCID 123707806-Methyl-2-phenyl-1,3-benzoxazole

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Benzoyl chloride (79 ml) was slowly added to a stirred suspension of 6-amino-m-cresol (83 gm) in pyridine (600 ml). The temperature was kept below 5° C. The solution was heated under reflux for 2 hr., then was evaporated to dryness to give an oil. This oil was extracted with aqueous 2N sodium hydroxide solution. The aqueous layer was made acid with cooncentrated hydrochloric acid. The solid, N-(2'-hydroxy-4'-methylbenzanilide), m.p. 170° C, was filtered off. This product was heated until no more water was evolved. The resulting liquid was allowed to cool and the solid produced was powdered and taken up in petroleum ether. The solution was treated with carbon and the filtrate evaporated to dryness to yield 6-methyl-2-phenylbenzoxazole, m.p. 93° C.

後処理

  1. customwas kept below 5° C
  2. temperatureThe solution was heated
  3. temperatureunder reflux for 2 hr
  4. custom, then was evaporated to dryness
  5. customto give an oil
  6. extractionThis oil was extracted with aqueous 2N sodium hydroxide solution
  7. filtrationThe solid, N-(2'-hydroxy-4'-methylbenzanilide), m.p. 170° C, was filtered off
  8. temperatureThis product was heated until no more water
  9. temperatureto cool
  10. customthe solid produced
  11. additionThe solution was treated with carbon
  12. customthe filtrate evaporated to dryness

出典と根拠

ORDレコード
ord-ac9ddc6fbb614a8693226521fbf57f3d
出典データセット
uspto-grants-1978_04
特許番号
USRE029608

反応ノート

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