Hydrochloric Acid → HCID 70166468、化合物

HRID 2083820ノート

反応式

HRID 2083820 の反応式
CO.[ClH:3].[CH3:4][O:5][C:6](=[O:33])[C@H:7]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=1)[NH:8][C:9](=[O:24])[C@H:10]([CH2:22][OH:23])[NH:11]C(OCC1C=CC=CC=1)=O.O>O1CCCC1.[Pd]>[ClH:3].[CH3:4][O:5][C:6](=[O:33])[C@H:7]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=1)[NH:8][C:9](=[O:24])[C@H:10]([CH2:22][OH:23])[NH2:11]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 962WaterHCID 13190522Z-Ser-Tyr-OMe

生成物 1

HCID 70166468HCID 70166468、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

Methanol (70 ml.) containing 6.67 ml. of 3N hydrogen chloride in tetrahydrofuran is added to a mixture of 8.328 g. of Nα -benzyloxycarbonyl-L-seryl-L-tyrosine methyl ester [cf. Fischer and Whetstone, J. Am. Chem. Soc., 76, 5076 (1954)] and 500 mg. of 20% palladium-on-carbon and the resulting mixture stirred under hydrogen at one inch water pressure for three hours. The mixture is filtered to remove the catalyst and the filtrate is evaporated to dryness under reduced pressure to give a residue of L-seryl-L-tyrosine methyl ester hydrochloride which is suitable for use without further purification.

後処理

  1. filtrationThe mixture is filtered
  2. customto remove the catalyst
  3. customthe filtrate is evaporated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-666658081b994ad580ca14b68fbb2b37
出典データセット
uspto-grants-1978_04
特許番号
US04086219

反応ノート

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