Hydrochloric Acid → L-tryptophyl-L-seryl-L-tyrosine methyl ester hydrochloride

HRID 2083822ノート

反応式

HRID 2083822 の反応式
CO.[ClH:3].[CH3:4][O:5][C:6](=[O:47])[C@H:7]([CH2:39][C:40]1[CH:45]=[CH:44][C:43]([OH:46])=[CH:42][CH:41]=1)[NH:8][C:9](=[O:38])[C@H:10]([CH2:36][OH:37])[NH:11][C:12](=[O:35])[C@H:13]([CH2:25][C:26]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[NH:28][CH:27]=1)[NH:14]C(OCC1C=CC=CC=1)=O>O1CCCC1.[Pd]>[ClH:3].[CH3:4][O:5][C:6](=[O:47])[C@H:7]([CH2:39][C:40]1[CH:41]=[CH:42][C:43]([OH:46])=[CH:44][CH:45]=1)[NH:8][C:9](=[O:38])[C@H:10]([CH2:36][OH:37])[NH:11][C:12](=[O:35])[C@H:13]([CH2:25][C:26]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[NH:28][CH:27]=1)[NH2:14]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 54186548HCID 54186548、化合物

生成物 1

HCID 70617527L-tryptophyl-L-seryl-L-tyrosine methyl ester hydrochloride

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

Methanol (75 ml.) containing 1.7 ml. of 3N hydrogen chloride in tetrahydrofuran is added to a mixture of 3.1 g. of Nα -benzyloxycarbonyl-L-tryptophyl-L-seryl-L-tyrosine methyl ester and 200 mg. of 20% palladium-on-carbon and the reaction is stirred under an atmosphere of hydrogen for two and a half hours. The mixture is filtered to remove the catalyst and the filtrate is evaporated under reduced pressure to give a residue of L-tryptophyl-L-seryl-L-tyrosine methyl ester hydrochloride which is suitable for use without further purification.

後処理

  1. filtrationThe mixture is filtered
  2. customto remove the catalyst
  3. customthe filtrate is evaporated under reduced pressure

出典と根拠

ORDレコード
ord-6c77b608e8c14205a382810b8a848044
出典データセット
uspto-grants-1978_04
特許番号
US04086219

反応ノート

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