Mesitylene → gamma-Chloroacetoacetylmesitylene

HRID 2084693

反応式

HRID 2084693 の反応式
[Cl:1][CH2:2][C:3](=[O:8])[CH2:4][C:5](Cl)=[O:6].[C:9]1([CH3:17])[CH:14]=[C:13]([CH3:15])[CH:12]=[C:11]([CH3:16])[CH:10]=1>FC(F)(F)S([O-])(=O)=O.[Sc+3].FC(F)(F)S([O-])(=O)=O.FC(F)(F)S([O-])(=O)=O.O>[Cl:1][CH2:2][C:3](=[O:8])[CH2:4][C:5]([C:10]1[C:11]([CH3:16])=[CH:12][C:13]([CH3:15])=[CH:14][C:9]=1[CH3:17])=[O:6]

参加物

5

反応物 2

HCID 7947MesityleneHCID 30162624-Chloro-3-oxobutyryl chloride

生成物 1

HCID 22734549gamma-Chloroacetoacetylmesitylene

試薬・触媒・溶媒 2

HCID 2734571Scandium(III) triflate触媒HCID 962Water溶媒

反応条件

温度
24 °C

実験手順

4-Chloroacetoacetyl chloride (35% strength solution in dichloromethane, 26.2 g, 59 mmol), mesitylene (7.4 g, 59 mmol, and scandium trifluoro-methanesulphonate (2.6 g, 5.1 mmol) were introduced at 20° C. The reaction mixture was then stirred at 24° C. for a total of 2 days. It was then hydrolysed with water (10 ml). The organic phase was concentrated, and the residue was dried in a high vacuum. 9.1 g of crude product were obtained.

後処理

  1. concentrationThe organic phase was concentrated
  2. customthe residue was dried in a high vacuum

出典と根拠

ORDレコード
ord-c093ba90add34e0090fee5360639f16b
出典データセット
uspto-grants-2004_04
特許番号
US06716999B2

関連ノート

読み込み中…