Ammonia → 5-Bromo-3-iodo-4-methylpyridin-2-amine
反応式
[Br:1][C:2]1[C:3]([CH3:9])=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.[I:10]N1C(=O)CCC1=O.FC(F)(F)C(O)=O.N>C(O)(=O)C>[Br:1][C:2]1[C:3]([CH3:9])=[C:4]([I:10])[C:5]([NH2:8])=[N:6][CH:7]=1参加物
6
実験手順
5-Bromo-4-methylpyridine-2-amine (3.1 g) was dissolved in acetic acid (20 ml). N-Iodosuccinimide (3.8 g) and trifluoroacetic acid (0.2 ml) were added and the mixture was stirred at room temperature for 2.5 hours. The reaction solution was poured into ice water and neutralized with 28% aqueous ammonia. Then, the precipitated solid was collected by filtration, washed with water and dried to give the title compound (4.9 g).
後処理
- filtrationThen, the precipitated solid was collected by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-828b4177bc2d4c569dad569a1bb7cb65
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08436012B2
反応ノート
読み込み中…