Tetrahydrofuran → 3-{[(4-{[1-(5-Methoxy-3-methyl-1-benzofuran-2-yl)-3-methylbutyl]amino}phenyl)carbonyl]amino}propanoic acid

To a mixture of ethyl 3-{[(4-{[1-(5-methoxy-3-methyl-1-benzofuran-2-yl)-3-methylbutyl]amino}phenyl)carbonyl]amino}propanoate (266 mg) synthesized above, tetrahydrofuran (5 mL) and ethanol (5 mL) was added 1N aqueous sodium hydroxide solution (2.00 mL), and the mixture was stirred at room temperature for 2 hr, and concentrated under reduced pressure. The residue was dissolved in water (10 mL), and 1N hydrochloric acid (2.00 mL) was added at 0° C. The resulting precipitate was collected by filtration to give the title object compound (216 mg, 86%) as a white solid.

1. concentrationconcentrated under reduced pressure
2. dissolutionThe residue was dissolved in water (10 mL)
3. addition1N hydrochloric acid (2.00 mL) was added at 0° C
4. filtrationThe resulting precipitate was collected by filtration

ORDレコード

ord-d4ccc140f0a0429bb6bdfc30bc4bdeb3

出典データセット

uspto-grants-2013_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08436043B2