Tetrahydrofuran → 3-{[(4-{[Cyclohexyl(3-methylthieno[2,3-c]pyridin-2-yl)methyl]amino}phenyl)carbonyl]amino}propanoic acid

To a mixture of ethyl 3-{[(4-{[cyclohexyl(3-methylthieno[2,3-c]pyridin-2-yl)methyl]amino}phenyl)carbonyl]amino}propanoate (209 mg) synthesized above, tetrahydrofuran (5 mL) and ethanol (5 mL) was added 1N aqueous sodium hydroxide solution (1.00 mL), and the mixture was stirred at room temperature for 1 hr, and concentrated under reduced pressure. The residue was dissolved in water (10 mL), and 1N hydrochloric acid (1.00 mL) was added at 0° C. The resulting precipitate was collected by filtration to give the title object compound (169 mg, 86%) as a white solid.

1. concentrationconcentrated under reduced pressure
2. dissolutionThe residue was dissolved in water (10 mL)
3. addition1N hydrochloric acid (1.00 mL) was added at 0° C
4. filtrationThe resulting precipitate was collected by filtration

ORDレコード

ord-39dd77cc6c754860a66beeb54b2af47f

出典データセット

uspto-grants-2013_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08436043B2