Water → 1-(5-Fluoro-3-methyl-1-benzofuran-2-yl)-2-methylpropan-1-ol

HRID 2091404ノート

反応式

HRID 2091404 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10](=[O:14])[CH:11]([CH3:13])[CH3:12])=[C:7]([CH3:15])[C:6]=2[CH:16]=1.[BH4-].[Na+].O>CO.O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH:10]([OH:14])[CH:11]([CH3:12])[CH3:13])=[C:7]([CH3:15])[C:6]=2[CH:16]=1

参加物

6

反応物 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 667778481-(5-Fluoro-3-methyl-1-benzofuran-2-yl)-2-methylpropan-1-one

生成物 1

HCID 667782941-(5-Fluoro-3-methyl-1-benzofuran-2-yl)-2-methylpropan-1-ol収率 100%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

1-(5-Fluoro-3-methyl-1-benzofuran-2-yl)-2-methylpropan-1-one (11.66 g) synthesized above was dissolved in methanol (4 mL)-tetrahydrofuran (20 mL), and sodium tetrahydroborate (90%) (446 mg) was added to the solution at 0° C. The reaction mixture was stirred at 0° C. for 1 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated to give the title compound (1.193 g, 100%) as a colorless oil.

後処理

  1. additionwas added to the solution at 0° C
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationAfter filtration
  6. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-043773e47d9b4a219fafa5132db18734
出典データセット
uspto-grants-2013_05
特許番号
US08436043B2

反応ノート

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