Nitric Acid → N-[4-(dimethylamino)-2-nitrophenyl]acetamide

HRID 2093041

反応式

HRID 2093041 の反応式
[CH3:1][N:2]([CH3:13])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:12])[CH3:11])=[CH:5][CH:4]=1.[N+:14]([O-])([OH:16])=[O:15].OS(O)(=O)=O>>[CH3:13][N:2]([CH3:1])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:12])[CH3:11])=[C:5]([N+:14]([O-:16])=[O:15])[CH:4]=1

参加物

4

反応物 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 819684'-Dimethylaminoacetanilide

生成物 1

HCID 4396139N-[4-(dimethylamino)-2-nitrophenyl]acetamide

実験手順

N-[4-(dimethylamino)phenyl]acetamide obtained in step I above was nitrated using nitric acid (1.2 eq)+H2SO4 (1.0 eq) at 0 to 5° C. for 2 hrs. After the completion of the reaction, reaction mixture was added to ice and pH was adjusted to 8, extracted with dichloromethane, which was evaporated to dryness to obtain N-[4-(dimethylamino)-2-nitrophenyl]acetamide.

後処理

  1. customat 0 to 5° C.
  2. customfor 2 hrs
  3. customAfter the completion of the reaction, reaction mixture
  4. additionwas added to ice and pH
  5. extractionextracted with dichloromethane, which
  6. customwas evaporated to dryness

出典と根拠

ORDレコード
ord-d2a14774e774469797592a2ed1dfd384
出典データセット
uspto-grants-2013_05
特許番号
US08440830B2

関連ノート

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