Formaldehyde → tert-butyl 4,5-Dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
反応式
[C:1]([O:5][C:6](=[O:15])[NH:7][CH2:8][CH2:9][C:10]1[CH:14]=[CH:13][S:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].C=O.[CH3:18]C1C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[S:12]1[C:11]2[CH2:18][N:7]([C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:15])[CH2:8][CH2:9][C:10]=2[CH:14]=[CH:13]1参加物
5
実験手順
To a solution of tert-butyl[2-(3-thienyl)ethyl]carbamate in toluene was added paraformaldehyde (2 equi.) and catalytic amount of PTSA and reaction mixture was then refluxed in dean stark apparatus for 4 hrs. Reaction mass wan then concentrated and extracted with dichloromethane dried over sodium sulphate and evaporated to yield tert-butyl 4,7-dihydrothieno[2,3-c]pyridine-6(5H)— carboxylate.
後処理
- temperaturewas then refluxed in dean stark apparatus for 4 hrs
- customReaction mass
- concentrationwan then concentrated
- extractionextracted with dichloromethane
- dry with materialdried over sodium sulphate
- customevaporated
出典と根拠
- ORDレコード
- ord-b043a35771784d9eb6582b7dc61ab5b2
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08440830B2
反応ノート
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